Research

PhenoMaster is an animal-friendly apparatus, creating home-like, stress-reduced environment for tested subjects. 

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Generation of animal models

The facility provides services for the production of genetically modified animals and viral vectors.

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Analysis of
animal models

The facility provides services for the behavioral examination of animals (mice and rats).

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Viral vectors technology

We produce of HIV-derived lentivectors, which are extensively used in the scientific...

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a list of transgenic animals produced in our facility: 

  • Tet-GFP transgenic rat with tetracycline control of gene expression (Konopka 2009),
  • cFos : PSD95-Venus : Arc transgenic rats
  • Syn MMP9 transgenic rat model with neurospecific overexpression of MMP-9 ((Wilczynski 2008).
  • Syn-Flag-ICER transgenic rat model with neurospecific overexpression of ICER (Inducible cAMP Early Repressor)
  • Syn-TDP43 transgenic rat model with neurospecific overexpression of TDP-43, (LV mediated transgenesis)
  • Thy1-Tweety transgenic rat model with neurospecific overexpression of Tweety gene (in cooperation with prof. Katarzyna Łukasiuk, Nencki Institute , NCN OPUS grant)
  • Tph-DREADD-mCherry transgenic rat model with serotoninergic specific overexpression of activating DREADD (Designer Receptors Exclusively Activated by Designer Drugs) in cooperation with prof. Urszula Sławinska, Nencki Institute , NCN OPUS grant)
  • 3 transgenic mice lines with neurospecific overexpression of Thy1-ORAI1, Thy-STIM-1, THY1-STIM-2 (or further studies on Alzheimer Disease development (for prof. Jacek Kuźnicki, IIMCB PAS Warsaw)
  • 3 transgenic mice models for opioid system studies (with overexpression of Drdla BAC, DAT-OPRK-1 KD-BAC and Dbh-BAC (for dr Jan Rodriguez-Parkitna, Pharmacology Institute PAS Kraków)
  • NWC transgenic mice model for the studies on immunological system development (In cooperation with Hirszfeld Immunology and Experimental Therapy Institute PAS, Poznań)

The mission of the Laboratory of Animal Models is the generation and analysis of  animal models. Our main goal is to determine the effect of genetic modification on the behavior and metabolism of the tested animal. Laboratory has latest technology equipment for the production of genetically modified animals and then to study the so-produced models.

In addition, the laboratory serves as a "core-facility”, currently being developed thanks to funding of the Foundation for Polish Science Team Tech Core Facility Plus project.  The facility provides services for the production and analysis of genetically modified animals, viral vector production and oncological studies. We offer service to scientific and R&D institutions worldwide.