Adeno associated vectors (AAV)
Adeno-associated viruses (AAVs) are replication-deficient parvoviruses, which have traditionally required co-infection with a helper adenovirus or herpes virus for productive infection. AAV has proven especially valuable for long-term gene expression due to the ability of AAV to replicate epichromosomally under replicationpermissive conditions. Slowly dividing or non-dividing cells can maintain the epichromosomal AAV genome over time, and gene expression will be stable while the AAV genome is maintained. Rapidly dividing cells will lose epichromosomal genome after cell replication and will, therefore, lose gene expression. Viral integration into the genome can occur, however, integration events are rare. We routinely produce AAV vectors of 1, 2 or 5 serotypes or as well mosaics.